InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gusb

Summary

InnateDB Protein

IDBP-202151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gusb

Protein Name

glucuronidase, beta

Synonyms

AI747421; asd; g; Gur; Gus; Gus-r; Gus-s; Gus-t; Gus-u; Gut;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026613

InnateDB Gene

IDBG-202149 (Gusb)

Protein Structure

UniProt Annotation

Function

Plays an important role in the degradation of dermatan and keratan sulfates.

Subcellular Localization

Lysosome {ECO:0000269PubMed:2394691}. Endoplasmic reticulum {ECO:0000269PubMed:2394691}. Note=A small proportion is found in the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004566	beta-glucuronidase activity

Biological Process

GO:0005975

carbohydrate metabolic process

Cellular Component

GO:0005764	lysosome
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95872

InterPro

IPR006101 Glycoside hydrolase, family 2
IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich
IPR006103 Glycoside hydrolase, family 2, TIM barrel
IPR006104 Glycosyl hydrolases family 2, sugar binding domain
IPR008979 Galactose-binding domain-like
IPR017853 Glycoside hydrolase, superfamily

PFAM

PF00703
PF02836
PF02837

PRINTS

PR00132

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P12265