InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phox2a

Summary

InnateDB Protein

IDBP-202177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phox2a

Protein Name

paired-like homeobox 2a

Synonyms

Arix; Phox2; Pmx2; Pmx2a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008090

InnateDB Gene

IDBG-202175 (Phox2a)

Protein Structure

UniProt Annotation

Function

May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0003357	noradrenergic neuron differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0021523	somatic motor neuron differentiation
GO:0021623	oculomotor nerve formation
GO:0021642	trochlear nerve formation
GO:0021703	locus ceruleus development
GO:0030901	midbrain development
GO:0043576	regulation of respiratory gaseous exchange
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048485	sympathetic nervous system development
GO:0048486	parasympathetic nervous system development