InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tpst1

Summary

InnateDB Protein

IDBP-202217.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpst1

Protein Name

protein-tyrosine sulfotransferase 1

Synonyms

R75054; Tango13a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035614

InnateDB Gene

IDBG-202215 (Tpst1)

Protein Structure

UniProt Annotation

Function

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0008476	protein-tyrosine sulfotransferase activity

Biological Process

GO:0006478	peptidyl-tyrosine sulfation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0000139	Golgi membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1298231

InterPro

IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00685

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O70281

PhosphoSite

PhosphoSite-O70281

TrEMBL

Q4FK50

UniProt Splice Variant

Entrez Gene

22021

UniGene

Mm.332720

RefSeq

NP_001123948

MGI ID

MGI Symbol

Tpst1

OMIM

CCDS

CCDS39293

HPRD

IMGT

EMBL

AC122339 AF038008 AK150753 BC012666 CH466529 CT010202

GenPept

AAC13551 AAH12666 BAE29823 CAJ18410 EDL19477 EDL19478