InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nradd

Summary

InnateDB Protein

IDBP-202226.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nradd

Protein Name

neurotrophin receptor associated death domain

Synonyms

2610311B09Rik; BB104149; NRDD; NRH2; PLAIDD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035069

InnateDB Gene

IDBG-202224 (Nradd)

Protein Structure

UniProt Annotation

Function

Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR. {ECO:0000269PubMed:12728256, ECO:0000269PubMed:12843241, ECO:0000269PubMed:19407813}.

Subcellular Localization

Cell membrane; Single-pass type III membrane protein. Nucleus. Note=Proteolytic processing gives rise to an intracellular domain that translocates to the nucleus.

Disease Associations

Tissue Specificity

Detected in lung and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005166	neurotrophin p75 receptor binding
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007420	brain development
GO:0009790	embryo development
GO:0010942	positive regulation of cell death

Cellular Component

GO:0005634	nucleus
GO:0005641	nuclear envelope lumen
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0032589	neuron projection membrane
GO:0044298	cell body membrane