InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pth1r

Summary

InnateDB Protein

IDBP-202325.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pth1r

Protein Name

parathyroid hormone 1 receptor

Synonyms

PPR; Pthr; Pthr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006005

InnateDB Gene

IDBG-202323 (Pth1r)

Protein Structure

UniProt Annotation

Function

This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004991	parathyroid hormone receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding
GO:0043621	protein self-association

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0002062	chondrocyte differentiation
GO:0002076	osteoblast development
GO:0006874	cellular calcium ion homeostasis
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0030282	bone mineralization
GO:0045453	bone resorption
GO:0048469	cell maturation
GO:0060732	positive regulation of inositol phosphate biosynthetic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97801

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR002170 GPCR, family 2, parathyroid hormone receptor
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR00393

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt