InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp9

Summary

InnateDB Protein

IDBP-202407.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Casp9

Protein Name

caspase 9

Synonyms

AI115399; APAF-3; AW493809; CASP-9; Caspase-9; ICE-LAP6; Mch6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030747

InnateDB Gene

IDBG-202405 (Casp9)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0007568	aging
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411	response to UV
GO:0014070	response to organic cyclic compound
GO:0032025	response to cobalt ion
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0034349	glial cell apoptotic process
GO:0034644	cellular response to UV
GO:0042770	signal transduction in response to DNA damage
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0046677	response to antibiotic
GO:0071407	cellular response to organic cyclic compound
GO:0071549	cellular response to dexamethasone stimulus
GO:2001020	regulation of response to DNA damage stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0043293	apoptosome

Protein Structure and Domains

PDB ID

MGI:1277950

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type

PFAM

PF00619
PF00656

PRINTS

PR00376

PIRSF

PIRSF038001

SMART

SM00114
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References