InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS37D

Summary

InnateDB Protein

IDBP-20243.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS37D

Protein Name

vacuolar protein sorting 37 homolog D (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000320416

InnateDB Gene

IDBG-20241 (VPS37D)

Protein Structure

UniProt Annotation

Function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Subcellular Localization

Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.

Disease Associations

Note=VPS37D is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0015031	protein transport
GO:0016032	viral process
GO:0016197	endosomal transport
GO:0019058	viral life cycle
GO:0019068	virion assembly
GO:0019082	viral protein processing
GO:0061024	membrane organization
GO:0075733	intracellular transport of virus