InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpc2

Summary

InnateDB Protein

IDBP-202477.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Trpc2

Protein Name

transient receptor potential cation channel, subfamily C, member 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091679

InnateDB Gene

IDBG-202473 (Trpc2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005216	ion channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015279	store-operated calcium channel activity
GO:0019992	diacylglycerol binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0000012	single strand break repair
GO:0002121	inter-male aggressive behavior
GO:0002124	territorial aggressive behavior
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007340	acrosome reaction
GO:0008050	female courtship behavior
GO:0010468	regulation of gene expression
GO:0019236	response to pheromone
GO:0048047	mating behavior, sex discrimination
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:1902436	negative regulation of male mating behavior

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032590	dendrite membrane

Protein Structure and Domains

PDB ID

MGI:109527

InterPro

IPR002153 Transient receptor potential channel, canonical
IPR002706 DNA-repair protein Xrcc1, N-terminal
IPR005458 Transient receptor potential channel, canonical 2
IPR005821 Ion transport domain
IPR008979 Galactose-binding domain-like
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR013555 Transient receptor ion channel domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF01834
PF00520
PF08016
PF08344
PF11929
PF12796

PRINTS

PR01097
PR01643

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R244