InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SAFB

Summary

InnateDB Protein

IDBP-20252.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAFB

Protein Name

scaffold attachment factor B

Synonyms

HAP; HET; SAF-B1; SAFB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000292123

InnateDB Gene

IDBG-20250 (SAFB)

Protein Structure

UniProt Annotation

Function

Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19674106}.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	74 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding