InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif3j1

Summary

InnateDB Protein

IDBP-202646.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif3j1

Protein Name

eukaryotic translation initiation factor 3, subunit J

Synonyms

1810016I04Rik; 2700079K05Rik; AA409117; AA409446; C78575; eIF-3-alpha-A; eIF-3-alpha-B; eIF3-alpha; eIF3-p35; Eif3j; Eif3j-1; Eif3j-2; eIF3j-A; eIF3j-B; Eif3j2; Eif3s1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028668

InnateDB Gene

IDBG-202644 (Eif3j1)

Protein Structure

UniProt Annotation

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA. {ECO:0000250UniProtKB:O75822, ECO:0000255HAMAP-Rule:MF_03009}.

Subcellular Localization

Cytoplasm {ECO:0000250UniProtKB:O75822, ECO:0000255HAMAP-Rule:MF_03009}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0006446	regulation of translational initiation

Cellular Component

GO:0005737	cytoplasm
GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex