Version 5.4
Mus musculus Protein: Gtf2ird1
Summary
InnateDB Protein IDBP-202726.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gtf2ird1
Protein Name general transcription factor II I repeat domain-containing 1
Synonyms 1700012P16Rik; BEN; Cream1; ESTM9; Gtf2il; GTF3; MusTRD1; Tg(Alb1-Myc)166.8Sst; WBSCR11; X83320;
Species Mus musculus
Ensembl Protein ENSMUSP00000098219
InnateDB Gene IDBG-202722 (Gtf2ird1)
Protein Structure
UniProt Annotation
Function May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8. {ECO:0000269PubMed:11438732}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00484, ECO:0000269PubMed:12780350}.
Disease Associations
Tissue Specificity Widely expressed.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0014886 transition between slow and fast fiber
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1861942
InterPro IPR004212 GTF2I-like repeat
IPR016659 Transcription factor II-I
PFAM PF02946
PRINTS
PIRSF PIRSF016441
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JI57
PhosphoSite PhosphoSite-
TrEMBL Q9EQE6
UniProt Splice Variant
Entrez Gene 57080
UniGene Mm.437004
RefSeq NP_001074937
MGI ID
MGI Symbol Gtf2ird1
OMIM
CCDS CCDS39303
HPRD
IMGT
EMBL AF247161 AF257475 AF260133 AF289666 AF289667 AF343348 AF343349 AF343350 AF343351 AF497637 AF497638 AF497639 AF497640 AF497641 AF497642 AH010164 AY030287 AY030288 AY030289
GenPept AAF78367 AAF99337 AAF99339 AAG44655 AAG44656 AAK49782 AAK49783 AAK49784 AAL68980 AAM02920 AAM02921 AAM02922 AAM02923 AAP30728 AAP30729 AAP30730 AAP30731 AAP30732 AAP30733

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca