InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Unc119

Summary

InnateDB Protein

IDBP-202786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Unc119

Protein Name

unc-119 homolog (C. elegans)

Synonyms

D11Bhm52; HRG4; MRG4; Rg4; Rtg4; Unc119h;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002127

InnateDB Gene

IDBG-202784 (Unc119)

Protein Structure

UniProt Annotation

Function

Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G- protein localization and trafficking in sensory neurons. Binds myristoylated NPHP3; however, in contrast to UNC119B, does not seem to play a major role in ciliary membrane localization of NPHP3. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells. {ECO:0000269PubMed:19781630, ECO:0000269PubMed:21642972}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Localized in photoreceptor synapses in the outer plexiform layer of the retina. {ECO:0000269PubMed:18296658}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.

Predicted by orthology
Total	85 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding

Biological Process

GO:0007109	cytokinesis, completion of separation
GO:0007601	visual perception
GO:0042953	lipoprotein transport
GO:0050896	response to stimulus
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:1900186	negative regulation of clathrin-mediated endocytosis
GO:2001287	negative regulation of caveolin-mediated endocytosis