Version 5.4
Mus musculus Protein: Duoxa2
Summary
InnateDB Protein IDBP-202862.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Duoxa2
Protein Name dual oxidase maturation factor 2
Synonyms 9030623N16Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000028656
InnateDB Gene IDBG-202860 (Duoxa2)
Protein Structure
UniProt Annotation
Function Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0015031 protein transport
GO:0042743 hydrogen peroxide metabolic process
GO:0050727 regulation of inflammatory response
GO:2000609 regulation of thyroid hormone generation
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1914061
InterPro IPR018469 Dual oxidase maturation factor
PFAM PF10204
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D311
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 66811
UniGene Mm.171333
RefSeq NP_080053
MGI ID
MGI Symbol Duoxa2
OMIM
CCDS CCDS16660
HPRD
IMGT
EMBL AK008816 AK018569 AL844566 BC031111
GenPept AAH31111 BAB25910 BAB31281 CAM16337

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca