InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vtn

Summary

InnateDB Protein

IDBP-202908.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vtn

Protein Name

vitronectin

Synonyms

AI256434; Vn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017488

InnateDB Gene

IDBG-202906 (Vtn)

Protein Structure

UniProt Annotation

Function

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0030247	polysaccharide binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0007160	cell-matrix adhesion
GO:0010811	positive regulation of cell-substrate adhesion
GO:0010951	negative regulation of endopeptidase activity
GO:0014911	positive regulation of smooth muscle cell migration
GO:0030198	extracellular matrix organization
GO:0032092	positive regulation of protein binding
GO:0033627	cell adhesion mediated by integrin
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0061302	smooth muscle cell-matrix adhesion

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle