InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eln

Summary

InnateDB Protein

IDBP-203190.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eln

Protein Name

elastin

Synonyms

AI385707; AI480567; E030024M20Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015138

InnateDB Gene

IDBG-203188 (Eln)

Protein Structure

UniProt Annotation

Function

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. {ECO:0000269PubMed:9607766}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix. Note=Extracellular matrix of elastic fibers.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030023	extracellular matrix constituent conferring elasticity
GO:0050840	extracellular matrix binding

Biological Process

GO:0001974	blood vessel remodeling
GO:0007519	skeletal muscle tissue development
GO:0030198	extracellular matrix organization
GO:0030833	regulation of actin filament polymerization
GO:0043149	stress fiber assembly