InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ksr1

Summary

InnateDB Protein

IDBP-203303.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ksr1

Protein Name

kinase suppressor of ras 1

Synonyms

AW492498; B-KSR1; D11Bhm183e; D11Bhm184e; hb; Ksr; RSU2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018478

InnateDB Gene

IDBG-203299 (Ksr1)

Protein Structure

UniProt Annotation

Function

Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000250}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.

Disease Associations

Tissue Specificity

Expressed in brain, spleen and testis. Isoform 1 is highly expressed spleen and weakly in testis, and isoform 2 is highly expressed in brain and weakly in testis. {ECO:0000269PubMed:10891492}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	65 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005078	MAP-kinase scaffold activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction
GO:0043410	positive regulation of MAPK cascade

Cellular Component

GO:0005789

endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

MGI:105051

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00130

PRINTS

PR00109

PIRSF

SMART

SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt