InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfrsf8

Summary

InnateDB Protein

IDBP-203325.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf8

Protein Name

tumor necrosis factor receptor superfamily, member 8

Synonyms

Cd30; D1S166E; Ki; Ki-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030339

InnateDB Gene

IDBG-203323 (Tnfrsf8)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in thymus and in activated splenocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043065	positive regulation of apoptotic process
GO:0045556	positive regulation of TRAIL biosynthetic process
GO:0071260	cellular response to mechanical stimulus