Version 5.4
Mus musculus Protein: Wsb1
Summary
InnateDB Protein IDBP-203400.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wsb1
Protein Name WD repeat and SOCS box-containing 1
Synonyms 1110056B13Rik; 2700038M07Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000017821
InnateDB Gene IDBG-203398 (Wsb1)
Protein Structure
UniProt Annotation
Function Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005575 cellular_component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID MGI:1926139
InterPro IPR001496 SOCS protein, C-terminal
IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF07525
PF00400
PRINTS PR00320
PIRSF
SMART SM00253
SM00969
SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54927
PhosphoSite PhosphoSite-O54927
TrEMBL Q8C841
UniProt Splice Variant
Entrez Gene 78889
UniGene Mm.474790
RefSeq NP_062627
MGI ID
MGI Symbol Wsb1
OMIM
CCDS CCDS25118
HPRD
IMGT
EMBL AF033186 AK048511 AK145974 AK146752 AK150394 AK150600 AK159905 AK167174 AK167394 AK169058 CH466556
GenPept AAB96647 BAC33353 BAE26797 BAE27409 BAE29522 BAE29692 BAE35469 BAE39310 BAE39483 BAE40846 EDL15604

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca