InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABHD11

Summary

InnateDB Protein

IDBP-20344.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABHD11

Protein Name

abhydrolase domain containing 11

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000222800

InnateDB Gene

IDBG-20342 (ABHD11)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Note=ABHD11 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:12073013}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0016787	hydrolase activity
GO:0016788	hydrolase activity, acting on ester bonds

Biological Process

GO:0006505	GPI anchor metabolic process
GO:0006886	intracellular protein transport
GO:0008150	biological_process
GO:0008152	metabolic process
GO:0009058	biosynthetic process

Cellular Component

GO:0005575	cellular_component
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR000073 Alpha/beta hydrolase fold-1
IPR000801 Putative esterase
IPR001031 Thioesterase
IPR012908 GPI inositol-deacylase PGAP1-like
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00561
PF00756
PF00975
PF07819

PRINTS

PR00111

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NFV4