InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DLK1

Summary

InnateDB Protein

IDBP-20351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLK1

Protein Name

delta-like 1 homolog (Drosophila)

Synonyms

Delta1; DLK; DLK-1; FA1; pG2; Pref-1; PREF1; ZOG;

Species

Homo sapiens

Ensembl Protein

ENSP00000340292

InnateDB Gene

IDBG-20347 (DLK1)

Protein Structure

UniProt Annotation

Function

May have a role in neuroendocrine differentiation.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007219	Notch signaling pathway
GO:0007275	multicellular organismal development
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045746	negative regulation of Notch signaling pathway
GO:0048706	embryonic skeletal system development