InnateDB Protein
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IDBP-203511.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rgs5
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Protein Name
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regulator of G-protein signaling 5
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Synonyms
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1110070A02Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000027997
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InnateDB Gene
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IDBG-203509 (Rgs5)
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Protein Structure
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Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in heart and muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005096
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GTPase activator activity
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Biological Process |
GO:0007165
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signal transduction
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GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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GO:0045744
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negative regulation of G-protein coupled receptor protein signaling pathway
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Cellular Component |
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PDB ID |
MGI:1098434
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InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
PF00615
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PRINTS |
PR01301
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
O08850
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
19737
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UniGene |
Mm.490759
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RefSeq |
NP_033089
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MGI ID |
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MGI Symbol |
Rgs5
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OMIM |
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CCDS |
CCDS15464
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HPRD |
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IMGT |
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EMBL |
AK004165
AK044096
AK054098
BC037683
U67188
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GenPept |
AAB50618
AAH37683
BAB23201
BAC31773
BAC35655
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