InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccr4

Summary

InnateDB Protein

IDBP-203514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr4

Protein Name

chemokine (C-C motif) receptor 4

Synonyms

C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062677

InnateDB Gene

IDBG-203512 (Ccr4)

Protein Structure

UniProt Annotation

Function

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol- calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000269PubMed:10811868}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in the thymus, macrophages and T- and B-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0001764	neuron migration
GO:0002507	tolerance induction
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0009314	response to radiation
GO:0009617	response to bacterium
GO:0046677	response to antibiotic
GO:0050927	positive regulation of positive chemotaxis
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:107824

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR002239 CC chemokine receptor 4
IPR005384 Duffy antigen/chemokine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00241
PR00237
PR00657
PR00645
PR01109
PR01559

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51680