InnateDB Protein
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IDBP-203591.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dync1li1
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Protein Name
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dynein cytoplasmic 1 light intermediate chain 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000035366
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InnateDB Gene
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IDBG-203589 (Dync1li1)
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Protein Structure
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Function |
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress throuh the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2135610
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InterPro |
IPR022780
Dynein family light intermediate chain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF05783
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R1Q8
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PhosphoSite |
PhosphoSite-Q8R1Q8
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TrEMBL |
Q3TWG5
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UniProt Splice Variant |
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Entrez Gene |
235661
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UniGene |
Mm.462644
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RefSeq |
NP_666341
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MGI ID |
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MGI Symbol |
Dync1li1
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OMIM |
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CCDS |
CCDS23595
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HPRD |
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IMGT |
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EMBL |
AK159702
AK159983
BC023347
CH466587
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GenPept |
AAH23347
BAE35301
BAE35534
EDL09299
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