InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbn1

Summary

InnateDB Protein

IDBP-203639.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbn1

Protein Name

fibrillin 1

Synonyms

AI536462; B430209H23; Fib-1; Tsk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028633

InnateDB Gene

IDBG-203635 (Fbn1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005201	extracellular matrix structural constituent
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001501	skeletal system development
GO:0001656	metanephros development
GO:0001822	kidney development
GO:0007507	heart development
GO:0071560	cellular response to transforming growth factor beta stimulus

Cellular Component

GO:0001527	microfibril
GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:95489

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011398 Fibrillin/Microneme protein4
IPR017878 TB domain

PFAM

PF00008
PF07645
PF00683

PRINTS

PIRSF

PIRSF036312

SMART

SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt