InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COG7

Summary

InnateDB Protein

IDBP-20377.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COG7

Protein Name

component of oligomeric golgi complex 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000305442

InnateDB Gene

IDBG-20375 (COG7)

Protein Structure

UniProt Annotation

Function

Required for normal Golgi function. {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:11980916}; Peripheral membrane protein {ECO:0000269PubMed:11980916}.

Disease Associations

Congenital disorder of glycosylation 2E (CDG2E) [MIM:608779]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N- glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269PubMed:15107842}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006486	protein glycosylation
GO:0006886	intracellular protein transport
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0033365	protein localization to organelle
GO:0034067	protein localization to Golgi apparatus
GO:0050821	protein stabilization