InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: REST

Summary

InnateDB Protein

IDBP-20384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

REST

Protein Name

RE1-silencing transcription factor

Synonyms

NRSF; XBR;

Species

Homo sapiens

Ensembl Protein

ENSP00000311816

InnateDB Gene

IDBG-20380 (REST)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. {ECO:0000269PubMed:12399542, ECO:0000269PubMed:19061646, ECO:0000269PubMed:7697725, ECO:0000269PubMed:7871435, ECO:0000269PubMed:8568247}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary. {ECO:0000269PubMed:8568247}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	62 [view]
Protein-Protein	56 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001046	core promoter sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0015271	outward rectifier potassium channel activity
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010629	negative regulation of gene expression
GO:0032348	negative regulation of aldosterone biosynthetic process
GO:0035690	cellular response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043922	negative regulation by host of viral transcription
GO:0045087	innate immune response (InnateDB)
GO:0045665	negative regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045955	negative regulation of calcium ion-dependent exocytosis
GO:0046676	negative regulation of insulin secretion
GO:0050768	negative regulation of neurogenesis
GO:0060379	cardiac muscle cell myoblast differentiation
GO:0070933	histone H4 deacetylation
GO:0071257	cellular response to electrical stimulus
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071805	potassium ion transmembrane transport
GO:2000065	negative regulation of cortisol biosynthetic process
GO:2000706	negative regulation of dense core granule biogenesis
GO:2000740	negative regulation of mesenchymal stem cell differentiation
GO:2000798	negative regulation of amniotic stem cell differentiation