InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gadl1

Summary

InnateDB Protein

IDBP-203866.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gadl1

Protein Name

glutamate decarboxylase-like 1

Synonyms

1110027M19Rik; ADC; CSADC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077694

InnateDB Gene

IDBG-203862 (Gadl1)

Protein Structure

UniProt Annotation

Function

May catalyze the decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in skeletal muscles and kidney (at protein level). {ECO:0000269PubMed:23038267}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004068	aspartate 1-decarboxylase activity
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0008150	biological_process
GO:0008152	metabolic process
GO:0019752	carboxylic acid metabolic process

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:1920998

InterPro

IPR000192 Aminotransferase, class V/Cysteine desulfurase
IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00266
PF01212
PF00282

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80WP8

PhosphoSite