Version 5.4
Mus musculus Protein: Atad5
Summary
InnateDB Protein IDBP-203889.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atad5
Protein Name ATPase family, AAA domain containing 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000017694
InnateDB Gene IDBG-203887 (Atad5)
Protein Structure
UniProt Annotation
Function Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis. {ECO:0000269PubMed:15983387}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed ubiquitously in all cell lines like teratocarcinoma, cell lymphoma, lymphoma. {ECO:0000269PubMed:15983387}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2442925
InterPro IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00004
PF07724
PF13304
PRINTS
PIRSF
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4QY64
PhosphoSite PhosphoSite-Q4QY64
TrEMBL
UniProt Splice Variant
Entrez Gene 237877
UniGene Mm.89551
RefSeq NP_001025027
MGI ID
MGI Symbol Atad5
OMIM
CCDS CCDS25127
HPRD
IMGT
EMBL AK032814 AK053857 AK085211 AK136531 AK165945 AL591113 AL663057 AL672178 AY557610 BC038279
GenPept AAH38279 AAT52048 BAC39389 BAE20483 BAE20694 BAE23031 BAE38477 CAI24765 CAI25200 CAI26037

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca