InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fcgr2b

Summary

InnateDB Protein

IDBP-203939.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fcgr2b

Protein Name

Fc receptor, IgG, low affinity IIb

Synonyms

AI528646; CD32; F630109E10Rik; Fc[g]RII; Fcgr2; Fcgr2a; FcgRII; Fcr-2; Fcr-3; fcRII; Ly-17; Ly-m20; LyM-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027966

InnateDB Gene

IDBG-203935 (Fcgr2b)

Protein Structure

UniProt Annotation

Function

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin- coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B- cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.Isoform IIB1: Cytoplasm, cytoskeleton. Note=Binds the cytoskeleton and is not localized in endocytotic pits.Isoform IIB3: Secreted. Note=Released as a soluble molecule.

Disease Associations

Tissue Specificity

Widely expressed by cells of hemopoietic origin. The isoforms are differentially expressed. Isoform IIB1 is preferentially expressed by cells of the lymphoid lineage, isoform IIB2 by cells of the myeloid lineage, and isoform IIB3 is released by macrophages and is present in the serum. Isoform IIB1' is expressed in myeloid and lymphoid cell lines, in normal spleen cells, and in resting or LPS-activated B-cells but is not detected in mesenteric lymph node cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	8 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0019864	IgG binding

Biological Process

GO:0001811	negative regulation of type I hypersensitivity
GO:0002638	negative regulation of immunoglobulin production
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006911	phagocytosis, engulfment
GO:0006952	defense response
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0009617	response to bacterium
GO:0016064	immunoglobulin mediated immune response
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030889	negative regulation of B cell proliferation
GO:0032693	negative regulation of interleukin-10 production
GO:0035556	intracellular signal transduction
GO:0050765	negative regulation of phagocytosis
GO:0050766	positive regulation of phagocytosis
GO:0050777	negative regulation of immune response
GO:0071219	cellular response to molecule of bacterial origin

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane