InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adap2

Summary

InnateDB Protein

IDBP-203969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adap2

Protein Name

ArfGAP with dual PH domains 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021050

InnateDB Gene

IDBG-203967 (Adap2)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity). {ECO:0000250, ECO:0000305}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding