InnateDB Protein
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IDBP-204096.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Azi2
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Protein Name
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5-azacytidine induced gene 2
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Synonyms
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AA410145; AZ2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000044350
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InnateDB Gene
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IDBG-204092 (Azi2)
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Protein Structure
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Function |
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. {ECO:0000269PubMed:17568778}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:10580148}.
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Disease Associations |
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Tissue Specificity |
Testis, ovary, heart, lung, kidney and brain. Expressed maily in the spermatocytes or spermatids in the testis. {ECO:0000269PubMed:10580148}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
24 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1351332
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QYP6
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PhosphoSite |
PhosphoSite-Q9QYP6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
27215
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UniGene |
Mm.92705
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RefSeq |
NP_038755
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MGI ID |
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MGI Symbol |
Azi2
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OMIM |
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CCDS |
CCDS40799
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HPRD |
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IMGT |
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EMBL |
AB007141
AK004992
AK015942
AK030076
AK036102
AK153477
AK165549
AK167783
BC006851
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GenPept |
AAH06851
BAA88213
BAB23727
BAB30044
BAC26770
BAE32027
BAE38249
BAE39815
BAE43294
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