InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hdc

Summary

InnateDB Protein

IDBP-204120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdc

Protein Name

histidine decarboxylase

Synonyms

AW108189; Hdc-a; Hdc-c; Hdc-e; Hdc-s;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028838

InnateDB Gene

IDBG-204118 (Hdc)

Protein Structure

UniProt Annotation

Function

Catalyzes the biosynthesis of histamine from histidine. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004398	histidine decarboxylase activity
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0001694	histamine biosynthetic process
GO:0006520	cellular amino acid metabolic process
GO:0006548	histidine catabolic process
GO:0019752	carboxylic acid metabolic process
GO:0042423	catecholamine biosynthetic process

Cellular Component

Protein Structure and Domains

PDB ID

MGI:96062

InterPro

IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR010977 Aromatic-L-amino-acid decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF01212
PF00282

PRINTS

PR00800

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P23738