InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eomes

Summary

InnateDB Protein

IDBP-204137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eomes

Protein Name

eomesodermin homolog (Xenopus laevis)

Synonyms

C77258; TBR-2; Tbr2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035020

InnateDB Gene

IDBG-204135 (Eomes)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. {ECO:0000269PubMed:10716450, ECO:0000269PubMed:14605368, ECO:0000269PubMed:18171685, ECO:0000269PubMed:18940588}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in CD8+ T-cells. {ECO:0000269PubMed:14605368}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	0
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001706	endoderm formation
GO:0001707	mesoderm formation
GO:0001714	endodermal cell fate specification
GO:0001824	blastocyst development
GO:0001829	trophectodermal cell differentiation
GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007420	brain development
GO:0010002	cardioblast differentiation
GO:0010468	regulation of gene expression
GO:0019827	stem cell maintenance
GO:0021772	olfactory bulb development
GO:0021796	cerebral cortex regionalization
GO:0021895	cerebral cortex neuron differentiation
GO:0030154	cell differentiation
GO:0032609	interferon-gamma production
GO:0035914	skeletal muscle cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045664	regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050767	regulation of neurogenesis
GO:0060706	cell differentiation involved in embryonic placenta development
GO:0060809	mesodermal to mesenchymal transition involved in gastrulation