InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGD5

Summary

InnateDB Protein

IDBP-20414.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGD5

Protein Name

FYVE, RhoGEF and PH domain containing 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000285046

InnateDB Gene

IDBG-20412 (FGD5)

Protein Structure

UniProt Annotation

Function

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. {ECO:0000269PubMed:22328776}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:22328776}. Cell projection, ruffle membrane {ECO:0000269PubMed:22328776}. Endoplasmic reticulum {ECO:0000269PubMed:22328776}. Golgi apparatus {ECO:0000269PubMed:22328776}. Early endosome {ECO:0000269PubMed:22328776}. Note=In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.

Disease Associations

Tissue Specificity

Expressed in endothelial cells (at protein level). {ECO:0000269PubMed:22328776}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0031267	small GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043088	regulation of Cdc42 GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0030027	lamellipodium
GO:0032587	ruffle membrane