InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Golga4

Summary

InnateDB Protein

IDBP-204158.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Golga4

Protein Name

golgi autoantigen, golgin subfamily a, 4

Synonyms

AI225887; AU019508; Olp-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081880

InnateDB Gene

IDBG-204154 (Golga4)

Protein Structure

UniProt Annotation

Function

May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12162805}. Golgi apparatus membrane {ECO:0000269PubMed:12162805}; Peripheral membrane protein {ECO:0000269PubMed:12162805}. Golgi apparatus {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in oligodendrocyte precursors, particularly at a stage just prior to myelination. {ECO:0000269PubMed:12162805}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0048037	cofactor binding
GO:0051020	GTPase binding

Biological Process

GO:0000042	protein targeting to Golgi
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0043001	Golgi to plasma membrane protein transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1859646

InterPro

IPR000237 GRIP
IPR009053 Prefoldin
IPR009079 Four-helical cytokine-like, core
IPR015083 Polyketide synthase, docking domain
IPR015988 STAT transcription factor, coiled coil

PFAM

PF01465
PF08990

PRINTS

PIRSF

SMART

SM00755

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91VW5