InnateDB Protein
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IDBP-204184.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Agtrap
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Protein Name
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angiotensin II, type I receptor-associated protein
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Synonyms
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3300002E14Rik; AT1R; Atrap; D4Wsu124e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000030865
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InnateDB Gene
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IDBG-204182 (Agtrap)
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Protein Structure
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Function |
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. {ECO:0000269PubMed:10358057, ECO:0000269PubMed:15757644}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous but more abundant in kidney, testis and heart. {ECO:0000269PubMed:10358057}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1339977
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InterPro |
IPR009436
Angiotensin II, type I receptor-associated
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PFAM |
PF06396
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PRINTS |
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PIRSF |
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SMART |
SM00805
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WVK0
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PhosphoSite |
PhosphoSite-Q9WVK0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11610
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UniGene |
Mm.46247
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RefSeq |
NP_033772
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MGI ID |
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MGI Symbol |
Agtrap
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OMIM |
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CCDS |
CCDS18930
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HPRD |
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IMGT |
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EMBL |
AF102548
AK007383
AK007502
AK036598
AK152467
AL606929
BC046820
BC057196
CH466594
CU207376
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GenPept |
AAD25997
AAH46820
AAH57196
BAB25001
BAB25074
BAC29501
BAE31243
CAM14899
CAQ51920
EDL14800
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