InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Draxin

Summary

InnateDB Protein

IDBP-204211.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Draxin

Protein Name

RIKEN cDNA 2610109H07 gene

Synonyms

2610109H07Rik; neucrin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030862

InnateDB Gene

IDBG-204209 (Draxin)

Protein Structure

UniProt Annotation

Function

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta- catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255HAMAP- Rule:MF_03060, ECO:0000269PubMed:19857465}.

Subcellular Localization

Secreted {ECO:0000255HAMAP-Rule:MF_03060}.

Disease Associations

Tissue Specificity

Predominantly expressed in developing neural tissues. Expressed in many brain regions, including the olfactory bulb, cortex, midbrain, cerebellum and pontine nuclei in postnatal day 0 (P0). Detected in the dorsal spinal cord and commissural axons. In the forebrain commissures, it is expressed in the regions that surround the corpus callosum, hippocampal commissure, and anterior commissure, such as the midline glial cells, indusium griseum glia, and glial wedge. {ECO:0000269PubMed:19150847, ECO:0000269PubMed:19857465}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007411	axon guidance
GO:0016055	Wnt signaling pathway
GO:0021516	dorsal spinal cord development
GO:0021528	commissural neuron differentiation in spinal cord
GO:0030517	negative regulation of axon extension
GO:0030900	forebrain development
GO:0043524	negative regulation of neuron apoptotic process
GO:0090090	negative regulation of canonical Wnt signaling pathway