InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GGA2

Summary

InnateDB Protein

IDBP-20430.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GGA2

Protein Name

golgi-associated, gamma adaptin ear containing, ARF binding protein 2

Synonyms

VEAR;

Species

Homo sapiens

Ensembl Protein

ENSP00000311962

InnateDB Gene

IDBG-20428 (GGA2)

Protein Structure

UniProt Annotation

Function

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:15039775}; Peripheral membrane protein {ECO:0000269PubMed:15039775}. Endosome membrane {ECO:0000269PubMed:15039775}; Peripheral membrane protein {ECO:0000269PubMed:15039775}.

Disease Associations

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030306	ADP-ribosylation factor binding

Biological Process

GO:0006886	intracellular protein transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005622	intracellular
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0010008	endosome membrane
GO:0030131	clathrin adaptor complex
GO:0030136	clathrin-coated vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR002014 VHS
IPR004152 GAT
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
IPR008153 Clathrin adaptor, gamma-adaptin, appendage
IPR008942 ENTH/VHS
IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
IPR018205 VHS subgroup

PFAM

PF00790
PF03127
PF02883

PRINTS

PIRSF

SMART

SM00809
SM00288

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UJY4