InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ubiad1

Summary

InnateDB Protein

IDBP-204357.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubiad1

Protein Name

UbiA prenyltransferase domain containing 1

Synonyms

1200002M06Rik; AI426463; AW320947; Tere1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058502

InnateDB Gene

IDBG-204355 (Ubiad1)

Protein Structure

UniProt Annotation

Function

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4- naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosyntetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004659	prenyltransferase activity
GO:0005515	protein binding
GO:0016209	antioxidant activity

Biological Process

GO:0001885	endothelial cell development
GO:0006744	ubiquinone biosynthetic process
GO:0009234	menaquinone biosynthetic process
GO:0042371	vitamin K biosynthetic process
GO:0072358	cardiovascular system development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030173	integral component of Golgi membrane