InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spaca3

Summary

InnateDB Protein

IDBP-204397.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spaca3

Protein Name

sperm acrosome associated 3

Synonyms

1700025M08Rik; ALLP17; Lyc3; mSLLP1; SLLP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099511

InnateDB Gene

IDBG-204393 (Spaca3)

Protein Structure

UniProt Annotation

Function

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305PubMed:15982649}; Single-pass type II membrane protein {ECO:0000305PubMed:15982649}. Note=Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

The processed form is expressed in sperm (at protein level). Expressed strongly in testis and epididymis and weakly in pancreas. {ECO:0000269PubMed:15982649, ECO:0000269PubMed:16014814}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003796	lysozyme activity
GO:0005515	protein binding

Biological Process

GO:0016998	cell wall macromolecule catabolic process
GO:0035036	sperm-egg recognition

Cellular Component

GO:0001669	acrosomal vesicle
GO:0002080	acrosomal membrane
GO:0005576	extracellular region
GO:0005764	lysosome
GO:0016021	integral component of membrane
GO:0030141	secretory granule

Protein Structure and Domains

PDB ID

MGI:1922872

InterPro

IPR000974 Glycoside hydrolase, family 22, lysozyme
IPR001916 Glycoside hydrolase, family 22
IPR023346 Lysozyme-like domain

PFAM

PF00062
PF13406

PRINTS

PR00137
PR00135

PIRSF

SMART

SM00263

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D9X8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

75622

UniGene

RefSeq

NP_083643

MGI ID

MGI Symbol

Spaca3

OMIM

CCDS

CCDS25136

HPRD

IMGT

EMBL

AK006357 AL645842 AY572448 AY601763 BC100503

GenPept

AAI00504 AAS77887 AAT07446 BAB24544 CAI24498