InnateDB Protein
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IDBP-204434.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Alkbh4
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Protein Name
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alkB, alkylation repair homolog 4 (E. coli)
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Synonyms
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2010004B12Rik; Abj4;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000098134
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InnateDB Gene
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IDBG-204430 (Alkbh4)
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Protein Structure
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Function |
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Midbody {ECO:0000250}. Note=Associates with the contractile ring and midbody. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003779
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actin binding
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GO:0016491
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oxidoreductase activity
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GO:0016706
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oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1919291
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InterPro |
IPR005123
Oxoglutarate/iron-dependent dioxygenase
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PFAM |
PF03171
PF13640
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D8F1
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PhosphoSite |
PhosphoSite-
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TrEMBL |
D3Z7X9
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UniProt Splice Variant |
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Entrez Gene |
72041
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UniGene |
Mm.486605
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RefSeq |
NP_082346
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MGI ID |
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MGI Symbol |
Alkbh4
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OMIM |
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CCDS |
CCDS19753
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HPRD |
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IMGT |
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EMBL |
AC087420
AK008083
BC022729
GL456122
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GenPept |
AAH22729
BAB25449
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