Version 5.4
Mus musculus Protein: Orai2
Summary
InnateDB Protein IDBP-204452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Orai2
Protein Name ORAI calcium release-activated calcium modulator 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000037137
InnateDB Gene IDBG-204450 (Orai2)
Protein Structure
UniProt Annotation
Function Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030426 growth cone
Protein Structure and Domains
PDB ID MGI:2443195
InterPro IPR012446 Calcium release-activated calcium channel protein
PFAM PF07856
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BH10
PhosphoSite PhosphoSite-Q8BH10
TrEMBL Q14BR6
UniProt Splice Variant
Entrez Gene 269717
UniGene Mm.397104
RefSeq NP_848866
MGI ID
MGI Symbol Orai2
OMIM
CCDS CCDS39326
HPRD
IMGT
EMBL AK036013 AK042940 AK079619 AM712356 AM712357 BC066070 BC115648 BC115649 CH466529
GenPept AAH66070 AAI15649 AAI15650 BAC29276 BAC31410 BAC37704 CAN36427 CAN36428 EDL19318

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca