InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sh2b2

Summary

InnateDB Protein

IDBP-204504.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sh2b2

Protein Name

SH2B adaptor protein 2

Synonyms

Aps;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005188

InnateDB Gene

IDBG-204502 (Sh2b2)

Protein Structure

UniProt Annotation

Function

Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Strongly expressed in brain; also expressed in spleen, kidney and skeletal muscle, and at low levels in small intestine and bone marrow. Strongly expressed in B-cell lines, but not T-cell lines. Also expressed in myeloid and fibroblast cell lines. {ECO:0000269PubMed:10872802}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0008269	JAK pathway signal transduction adaptor activity
GO:0042802	identical protein binding

Biological Process

GO:0001922	B-1 B cell homeostasis
GO:0007399	nervous system development
GO:0008286	insulin receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0019222	regulation of metabolic process
GO:0030036	actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0042593	glucose homeostasis
GO:0046325	negative regulation of glucose import
GO:0046425	regulation of JAK-STAT cascade
GO:0046578	regulation of Ras protein signal transduction
GO:0050776	regulation of immune response
GO:0050851	antigen receptor-mediated signaling pathway
GO:0050873	brown fat cell differentiation