InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccl8

Summary

InnateDB Protein

IDBP-204555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccl8

Protein Name

chemokine (C-C motif) ligand 8

Synonyms

1810063B20Rik; AB023418; HC14; MCP-2; Mcp2; Scya8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009329

InnateDB Gene

IDBG-204553 (Ccl8)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	1 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0008201	heparin binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0060326	cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Protein Structure and Domains

PDB ID

MGI:101878

InterPro

IPR001811 Chemokine interleukin-8-like domain

PFAM

PF00048

PRINTS

PIRSF

SMART

SM00199

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z121

PhosphoSite

PhosphoSite-

TrEMBL

Q149U7

UniProt Splice Variant

Entrez Gene

20307

UniGene

Mm.42029

RefSeq

NP_067418

MGI ID

MGI Symbol

Ccl8

OMIM

CCDS

CCDS36248

HPRD

IMGT

EMBL

AB023418 AK007942 BC117101 BC117103 CH466556 DS033261

GenPept

AAI17102 AAI17104 BAA75014 BAB25365 EDL01208 EDL15660