InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myd88

Summary

InnateDB Protein

IDBP-204567.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myd88

Protein Name

myeloid differentiation primary response gene 88

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035092

InnateDB Gene

IDBG-204565 (Myd88)

Protein Structure

UniProt Annotation

Function

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. {ECO:0000269PubMed:11909531, ECO:0000269PubMed:17018642, ECO:0000269PubMed:17635956, ECO:0000269PubMed:18941239, ECO:0000269PubMed:21998396, ECO:0000269PubMed:2374694, ECO:0000269PubMed:9575168, ECO:0000269PubMed:9697844}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17018642}.

Disease Associations

Tissue Specificity

Detected in bone marrow. Isoform 1 is expressed in testis, kidney, lung, ovary, adrenal gland, prostate, thymus and heart, and weakly in skeletal muscle, liver, spleen and brain. Isoform 2 is mainly expressed in the spleen and weakly in brain. {ECO:0000269PubMed:11909531, ECO:0000269PubMed:21998396, ECO:0000269PubMed:2374694, ECO:0000269PubMed:9013863, ECO:0000269PubMed:9575168}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Experimentally validated
Total	99 [view]
Protein-Protein	88 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	1 [view]
DNA-RNA	1 [view]

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005121	Toll binding
GO:0005149	interleukin-1 receptor binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0070976	TIR domain binding

Biological Process

GO:0002238	response to molecule of fungal origin
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007254	JNK cascade
GO:0008063	Toll signaling pathway
GO:0009615	response to virus
GO:0016064	immunoglobulin mediated immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032494	response to peptidoglycan
GO:0032496	response to lipopolysaccharide
GO:0032740	positive regulation of interleukin-17 production
GO:0032747	positive regulation of interleukin-23 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0042127	regulation of cell proliferation
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044130	negative regulation of growth of symbiont in host
GO:0045080	positive regulation of chemokine biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045351	type I interferon biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050727	regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070555	response to interleukin-1
GO:0070935	3'-UTR-mediated mRNA stabilization
GO:0071260	cellular response to mechanical stimulus
GO:0090557	establishment of endothelial intestinal barrier

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:108005

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000488 Death domain
IPR011029 Death-like domain
IPR017281 Myeloid differentiation primary response protein MyD88

PFAM

PF01582
PF13676
PF00531

PRINTS

PIRSF

PIRSF037756

SMART

SM00255
SM00005

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt