InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cct6b

Summary

InnateDB Protein

IDBP-204631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cct6b

Protein Name

chaperonin containing Tcp1, subunit 6b (zeta)

Synonyms

CCT-zeta-2; Cctz-2; CCTzeta-2; TCP-1-zeta-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021040

InnateDB Gene

IDBG-204629 (Cct6b)

Protein Structure

UniProt Annotation

Function

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). May have specific functions in the folding of testicular proteins and for interactions with testicular molecular chaperones. {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Testis specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005524	ATP binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0008150	biological_process
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005832

chaperonin-containing T-complex

Protein Structure and Domains

PDB ID

MGI:1329013

InterPro

IPR001844 Chaperonin Cpn60
IPR002423 Chaperonin Cpn60/TCP-1
IPR012722 T-complex protein 1, zeta subunit
IPR017998 Chaperone tailless complex polypeptide 1 (TCP-1)
IPR027409 GroEL-like apical domain

PFAM

PF00118

PRINTS

PR00298
PR00304

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61390