InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itln1

Summary

InnateDB Protein

IDBP-204666.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itln1

Protein Name

intelectin 1 (galactofuranose binding)

Synonyms

IntL; Itln; Itln2; Itln5; Itlna; Lfr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043837

InnateDB Gene

IDBG-204664 (Itln1)

Protein Structure

UniProt Annotation

Function

Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Secreted {ECO:0000250}. Note=Enriched in lipid rafts. {ECO:0000269PubMed:16866365}.

Disease Associations

Tissue Specificity

Expressed in small intestinal Paneth cells in uninfected mice. Expression also detected in various other tissues including stomach, kidney, ovary and brain. {ECO:0000269PubMed:15222482, ECO:0000269PubMed:15265922, ECO:0000269PubMed:16866365, ECO:0000269PubMed:16936804, ECO:0000269PubMed:9790983}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030246	carbohydrate binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0009624	response to nematode
GO:0046326	positive regulation of glucose import

Cellular Component

GO:0005576	extracellular region
GO:0031225	anchored component of membrane
GO:0031526	brush border membrane
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome