InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NOA1

Summary

InnateDB Protein

IDBP-20470.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NOA1

Protein Name

chromosome 4 open reading frame 14

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000264230

InnateDB Gene

IDBG-20466 (NOA1)

Protein Structure

UniProt Annotation

Function

Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP. {ECO:0000269PubMed:19103604}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:19103604}; Peripheral membrane protein {ECO:0000269PubMed:19103604}; Matrix side {ECO:0000269PubMed:19103604}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006915	apoptotic process
GO:0010941	regulation of cell death
GO:0032543	mitochondrial translation
GO:0042254	ribosome biogenesis
GO:0043457	regulation of cellular respiration