Version 5.4
Mus musculus Protein: Acvr2b
Summary
InnateDB Protein IDBP-204702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acvr2b
Protein Name activin receptor IIB
Synonyms ActRIIB;
Species Mus musculus
Ensembl Protein ENSMUSP00000035093
InnateDB Gene IDBG-204700 (Acvr2b)
Protein Structure
UniProt Annotation
Function Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019838 growth factor binding
GO:0034711 inhibin binding
GO:0046872 metal ion binding
GO:0048185 activin binding
Biological Process
GO:0001501 skeletal system development
GO:0001702 gastrulation with mouth forming second
GO:0001822 kidney development
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0006468 protein phosphorylation
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0009749 response to glucose
GO:0009791 post-embryonic development
GO:0009952 anterior/posterior pattern specification
GO:0009966 regulation of signal transduction
GO:0023014 signal transduction by phosphorylation
GO:0030073 insulin secretion
GO:0030324 lung development
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0031016 pancreas development
GO:0032147 activation of protein kinase activity
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0035265 organ growth
GO:0042475 odontogenesis of dentin-containing tooth
GO:0045669 positive regulation of osteoblast differentiation
GO:0048617 embryonic foregut morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0060021 palate development
GO:0060836 lymphatic endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0061298 retina vasculature development in camera-type eye
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:87912
InterPro IPR000333 Ser/Thr protein kinase, TGFB receptor
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF01064
PF00069
PF07714
PRINTS PR00653
PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P27040
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 11481
UniGene
RefSeq
MGI ID 2H64
MGI Symbol Acvr2b
OMIM
CCDS
HPRD
IMGT
EMBL BC106189 M84120
GenPept AAA37172 AAI06190

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca