Version 5.4
Mus musculus Protein: Ciao1
Summary
InnateDB Protein IDBP-204713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ciao1
Protein Name cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae)
Synonyms AW210570; Wdr39;
Species Mus musculus
Ensembl Protein ENSMUSP00000003759
InnateDB Gene IDBG-204711 (Ciao1)
Protein Structure
UniProt Annotation
Function Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. {ECO:0000255HAMAP-Rule:MF_03037}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007059 chromosome segregation
GO:0016226 iron-sulfur cluster assembly
Cellular Component
GO:0071817 MMXD complex
GO:0097361 CIA complex
Protein Structure and Domains
PDB ID MGI:1346998
InterPro IPR001680 WD40 repeat
IPR006849 IKI3
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PF04762
PRINTS
PIRSF PIRSF017233
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99KN2
PhosphoSite PhosphoSite-Q99KN2
TrEMBL
UniProt Splice Variant
Entrez Gene 26371
UniGene Mm.459513
RefSeq NP_079572
MGI ID
MGI Symbol Ciao1
OMIM
CCDS CCDS16696
HPRD
IMGT
EMBL AK002314 AK028376 AL845368 BC004089
GenPept AAH04089 BAB22008 BAC25915 CAM17441

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca